(19)
(11) EP 1 118 328 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
published in accordance with Art. 158(3) EPC

(48) Corrigendum issued on:
10.04.2002 Bulletin 2002/15

(43) Date of publication:
25.07.2001 Bulletin 2001/30

(21) Application number: 00949898.1

(22) Date of filing: 26.07.2000
(51) International Patent Classification (IPC)7: A61K 31/663, A61P 19/00, A61P 43/00, A61F 2/28
// C07F9:38
(86) International application number:
PCT/JP0004/974
(87) International publication number:
WO 0108/690 (08.02.2001 Gazette 2001/06)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 02.08.1999 JP 21846499

(71) Applicant: TORAY INDUSTRIES, INC.
Tokyo 103-8666 (JP)

(72) Inventors:
  • Ito, Masatoshi
    Yokohama-shi Kanagawa 235-0023 (JP)
  • Kawai, Yuriko
    Kamakura-shi Kanagawa 248-0034 (JP)
  • Okazaki, Seiji
    Kamakura-shi Kanagawa 248-0034 (JP)
  • Tanahashi, Masahiko
    Kamakura-shi Kanagawa 248-0034 (JP)
  • Kim, Kang, Jung
    Tokyo 102-0085 (JP)
  • Iwase, Miho
    Chigasaki-shi Kanagawa 253-0008 (JP)

(74) Representative: Coleiro, Raymond et al
MEWBURN ELLIS York House 23 Kingsway
London WC2B 6HP
London WC2B 6HP (GB)

   


(54) INSERTION STABILIZERS FOR IMPLANTS


(57) The present invention relates to an implant attachment stabilizer having, as an effective component, a methanebisphosphonic acid derivative represented by general formula (I) [where, in the formula, X, Y, m, n, ยทยทยท, A, B, R1, R2, R3 and R4 are as defined in the Specification], or hydrate thereof.
The methanebisphosphonic acid derivatives represented by general formula (I) or the hydrates thereof, to which the present invention relates, have an interstitial tissue proliferation inhibiting action and an osteolytic factor production inhibiting action and, in particular, since they inhibit osteolysis through the inhibition of the interstitial tissue proliferation which accompanies implant attachment and the inhibition of osteolysis factor production at the implant periphery, they are effective in the prevention of implant loosening and detachment, and it is possible to extend the implant attachment period in the case of implants such as artificial joints, and implants in the oro-dental field.