(19)

(11)

EP 1 119 352 A1

(12)

(43) Date of publication: 01.08.2001 Bulletin 2001/31 (21) Application number: 00961334.0 (22) Date of filing: 09.08.2000

(51) International Patent Classification (IPC)7: A61K 31/24 (86) International application number: PCT/US0021/784 (87) International publication number: WO 0124/794 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.08.1999 US 147965 P (71) Applicant: The Webb-Waring Institute for Biomedical Research Denver, CO 80262 (US)	(72) Inventor: REPINE, John, E. Englewood, CO 80110 (US) (74) Representative: Evens, Paul Jonathan et al Maguire Boss,5 Crown Street St. Ives,Cambridge PE27 5EB St. Ives,Cambridge PE27 5EB (GB)