(19)

(11)

EP 1 119 372 A1

(12)

(43) Date of publication: 01.08.2001 Bulletin 2001/31 (21) Application number: 99951477.1 (22) Date of filing: 06.10.1999

(51) International Patent Classification (IPC)7: A61K 45/06, A61P 37/08 (86) International application number: PCT/US9921/438 (87) International publication number: WO 0021/564 (20.04.2000 Gazette 2000/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.10.1998 US 169609 (71) Applicant: SCHERING CORPORATION Kenilworth, NJ 07030 (US)	(72) Inventor: SHIH, Neng-Yang North Caldwell, NJ 07006 (US) (74) Representative: Ritter, Stephen David et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)