(19)

(11)

EP 1 119 642 A1

(12)

(43) Date of publication: 01.08.2001 Bulletin 2001/31 (21) Application number: 99942265.2 (22) Date of filing: 19.08.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, C07H 21/04, A61K 48/00, C12N 15/00, C12N 15/85 (86) International application number: PCT/US9918/726 (87) International publication number: WO 0011/217 (02.03.2000 Gazette 2000/09)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.08.1998 US 97098 P (71) Applicant: University of Maryland, Baltimore Baltimore,Maryland 21201 (US)	(72) Inventors: MALONE, Robert, W. Baltimore, MD 21230 (US) MALONE, Jill, G. Baltimore, MD 21230 (US) (74) Representative: Olgemöller, Luitgard, Dr.  Leonhard - Olgemöller - Fricke,Patentanwälte,Postfach 10 09 57 80083 München 80083 München (DE)