(19)

(11)

EP 1 121 371 A1

(12)

(43) Date of publication: 08.08.2001 Bulletin 2001/32 (21) Application number: 99930140.1 (22) Date of filing: 02.06.1999

(51) International Patent Classification (IPC)7: C07H 19/06, C07H 19/16, C07H 21/00, C07H 19/20, C12Q 1/68 (86) International application number: PCT/US9912/323 (87) International publication number: WO 0021/974 (20.04.2000 Gazette 2000/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.10.1998 US 172789 (71) Applicant: PE Corporation (NY) Foster City, CA 94404 (US)	(72) Inventors: KAHN, Shaheer, H. Foster City, CA 94404 (US) ROSENBLUM, Barnett, B. San Jose, CA 95118 (US) ZHEN, Weiguo Foster City, CA 94404 (US) MENCHEN, Steven, M. Fremont, CA 94536 (US) (74) Representative: Grund, Martin, Dr. et al Dr. Volker VossiusPatentanwaltskanzleiHolbeinstrasse 5 81679 München 81679 München (DE)