(19)
(11) EP 1 121 374 A1

(12)

(43) Date of publication:
08.08.2001 Bulletin 2001/32

(21) Application number: 99953208.8

(22) Date of filing: 15.10.1999
(51) International Patent Classification (IPC)7C07H 21/04, C07K 14/00, C07K 16/00, C12N 15/00, C12N 15/63, C12N 15/85, C12N 15/86
(86) International application number:
PCT/US9924/263
(87) International publication number:
WO 0021/976 (20.04.2000 Gazette 2000/16)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 15.10.1998 US 104416 P

(71) Applicant: THE GENERAL HOSPITAL CORPORATION
Boston, MA 02114 (US)

(72) Inventors:
  • DEMAY, Marie, B.
    Boston, MA 02214 (US)
  • KEARNS, Ann
    Boston, MA 02214 (US)

(74) Representative: Grund, Martin, Dr. et al
Dr. Volker Vossius,Patentanwaltskanzlei,Holbeinstrasse 5
81679 München
81679 München (DE)

   


(54) BONE MORPHOGENIC PROTEIN-INDUCED GENES AND POLYPEPTIDES, AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC METHODS