(19)

(11)

EP 1 121 419 A1

(12)

(43) Date of publication: 08.08.2001 Bulletin 2001/32 (21) Application number: 99952028.1 (22) Date of filing: 19.10.1999

(51) International Patent Classification (IPC)7: C12N 5/10, C12N 15/12, C12N 15/19, C12N 15/28, C12N 15/63, C12N 15/64, C07K 14/47, C07K 14/52, C07K 14/525 (86) International application number: PCT/US9924/413 (87) International publication number: WO 0023/572 (27.04.2000 Gazette 2000/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.10.1998 US 104950 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: NI, Jian Rockville, MD 20853 (US) RUBEN, Steven, M. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)