IN VITRO AND IN VIVO MODELS FOR SCREENING COMPOUNDS TO PREVENT GLUCOCORTICOID-INDUCED BONE DESTRUCTION - Patent 1121456

(19)

(11)

EP 1 121 456 A1

(12)

(43)	Date of publication:
	08.08.2001 Bulletin 2001/32

(21)	Application number: 99951842.6

(22)	Date of filing: 07.10.1999

(51)	International Patent Classification (IPC)⁷: C12Q 1/00, C12Q 1/02, A61K 49/00, A61P 19/10

(86)	International application number:
	PCT/US9923/395

(87)	International publication number:
	WO 0020/625 (13.04.2000 Gazette 2000/15)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

(30)

Priority:

07.10.1998 US 103385 P
27.10.1998 US 105805 P
19.01.1999 US 116409 P

(71)	Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
	Little Rock, AR 72207-3608 (US)

(72)	Inventors:
	MANOLAGAS, Stavros, C. Little Rock, AR 72227 (US) JILKA, Robert, L. Little Rock, AR 72211 (US) WEINSTEIN, Robert, S. Little Rock, AR 72211 (US) BELLIDO, Teresita Little Rock, AR 72211 (US)

(74)	Representative: Hallybone, Huw George et al
	CARPMAELS AND RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)

(54)	IN VITRO AND IN VIVO MODELS FOR SCREENING COMPOUNDS TO PREVENT GLUCOCORTICOID-INDUCED BONE DESTRUCTION