(19)

(11)

EP 1 121 598 A1

(12)

(43) Date of publication: 08.08.2001 Bulletin 2001/32 (21) Application number: 99951799.8 (22) Date of filing: 06.10.1999

(51) International Patent Classification (IPC)7: G01N 33/574, G01N 33/48 (86) International application number: PCT/US9923/220 (87) International publication number: WO 0020/869 (13.04.2000 Gazette 2000/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.10.1998 US 103197 P (71) Applicant: GEORGETOWN UNIVERSITY Washington, DC 20007 (US)	(72) Inventors: WELLSTEIN, Anton Washington, DC 20007 (US) SOUTTOU, Boussad 75005 Paris (FR) RAULAI, Daniel 75005 Paris (FR) VIGNY, Marc 75005 Paris (FR) (74) Representative: Daniels, Jeffrey Nicholas et al Page White & Farrer54 Doughty Street London WC1N 2LS London WC1N 2LS (GB)