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(11)

EP 1 123 095 A1

(12)

(43) Date of publication: 16.08.2001 Bulletin 2001/33 (21) Application number: 99955021.3 (22) Date of filing: 15.10.1999

(51) International Patent Classification (IPC)7: A61K 31/34, A61K 31/40, A61K 31/38 (86) International application number: PCT/US9924/361 (87) International publication number: WO 0023/071 (27.04.2000 Gazette 2000/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.10.1998 US 173903 (71) Applicant: Millennium Pharmaceuticals, Inc. Cambridge,Massachusetts 02139 (US)	(72) Inventors: YEH, C., Grace Marlboro, MA 01752 (US) DOW, Gordon, J. Santa Rosa, CA 95409 (US) LATHROP, Robert, W. Novato, CA 94949 (US) CHORGHADE, Mukund, S. Wellesley, MA 02481-3312 (US) RAO, Alla Verkata Rama Habsiguda,Hyderabad 50007 (IN) (74) Representative: Albrecht, Thomas, Dr.  Kraus & Weisert,Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)