(19)

(11)

EP 1 123 277 A1

(12)

(43) Date of publication: 16.08.2001 Bulletin 2001/33 (21) Application number: 99949136.8 (22) Date of filing: 22.09.1999

(51) International Patent Classification (IPC)7: C07D 209/52, C07D 401/04, A61K 31/4427 (86) International application number: PCT/GB9903/175 (87) International publication number: WO 0023/424 (27.04.2000 Gazette 2000/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.10.1998 GB 9822945 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)	(72) Inventors: HODGSON, D. M.,Dyson Perrins Lab.Univ. of Oxford Oxford OX1 3QY (GB) MAXWELL, C. R.,Dyson Perrins Lab.Univ. of Oxford Oxford OX1 3QY (GB) (74) Representative: Ellis-Jones, Patrick George Armine  J.A. KEMP & CO.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)