(19)

(11)

EP 1 123 317 A1

(12)

(43) Date of publication: 16.08.2001 Bulletin 2001/33 (21) Application number: 99949212.7 (22) Date of filing: 12.10.1999

(51) International Patent Classification (IPC)7: C07K 16/46, C12N 15/00 (86) International application number: PCT/GB9903/386 (87) International publication number: WO 0023/477 (27.04.2000 Gazette 2000/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.10.1998 GB 9822763 (71) Applicant: The University Of Sheffield Sheffield, S10 2TN (GB)	(72) Inventor: HELM, Birgit A.,Krebs Inst.for Biomolecular Res. University of Sheffield,Sheffield (GB) (74) Representative: Allen, Philippa Margaret et al Markgraaf Patents LimitedThe Crescent54 Blossom Street York YO24 1AP York YO24 1AP (GB)