(19)

(11)

EP 1 124 574 A2

(12)

(88) Date of publication A3: 27.07.2000 (43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99951011.8 (22) Date of filing: 27.10.1999

(51) International Patent Classification (IPC)7: A61K 39/095, A61K 39/385 // (C07K7/06, G01N33:577) (86) International application number: PCT/GB9903/559 (87) International publication number: WO 0025/814 (11.05.2000 Gazette 2000/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.10.1998 GB 9823835 (71) Applicant: UNIVERSITY COLLEGE LONDON London NW3 2PF (GB)	(72) Inventors: CHARALAMBOUS, Bambos Michael Bedfordshire SG18 0PX (GB) FEAVERS, Ian Michael Hertfordshire AL4 8NR (GB) (74) Representative: Daniels, Jeffrey Nicholas et al Page White & Farrer54 Doughty Street London WC1N 2LS London WC1N 2LS (GB)