(19)

(11)

EP 1 124 581 A1

(12)

(43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 98956348.1 (22) Date of filing: 29.10.1998

(51) International Patent Classification (IPC)7: A61K 47/10, A61K 47/24 (86) International application number: PCT/US9823/014 (87) International publication number: WO 0025/822 (11.05.2000 Gazette 2000/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicants: Grasela, John C. San Diego, CA 92130 (US) Grasela, Joseph C. San Diego, CA 92109 (US) Jubenville, Robert M. San Diego, CA 92103 (US) McCloskey, Joseph J. Bloomfield Hills, MI 48302 (US)	(72) Inventors: Grasela, John C. San Diego, CA 92130 (US) Grasela, Joseph C. San Diego, CA 92109 (US) Jubenville, Robert M. San Diego, CA 92103 (US) McCloskey, Joseph J. Bloomfield Hills, MI 48302 (US) (74) Representative: Wilson, Nicholas Martin et al Withers & RogersGoldings House2 Hays Lane London SE1 2HW London SE1 2HW (GB)