(19)

(11)

EP 1 124 851 A1

(12)

(43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99971818.2 (22) Date of filing: 01.11.1999

(51) International Patent Classification (IPC)7: C07K 14/705, C07K 14/71, C07K 14/715, C12N 5/10, C12N 15/12, C12N 15/85, G01N 33/53 (86) International application number: PCT/US9925/617 (87) International publication number: WO 0027/882 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.11.1998 US 187711 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: KIKLY, Kristine, Kay Linfield, PA 19468 (US) MICHALOVICH, David Totenham Lane,Crouch End,London N8 8PT (GB) (74) Representative: Crump, Julian Richard John  FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)