(19)

(11)

EP 1 124 954 A2

(12)

(88) Date of publication A3: 01.02.2001 (43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99970999.1 (22) Date of filing: 22.10.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/86, C12N 7/01, C12N 5/10, C07K 14/435, A01N 63/02 (86) International application number: PCT/US9924/922 (87) International publication number: WO 0024/772 (04.05.2000 Gazette 2000/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.10.1998 US 105404 P (71) Applicant: E.I. DU PONT DE NEMOURS AND COMPANY WilmingtonDelaware 19898 (US)	(72) Inventors: MCCUTCHEN, Billy, F. Newark, DE 19808 (US) HERRMANN, Rafael Wilmington, DE 19810 (US) (74) Representative: Webber, Philip Michael et al Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)