(19)

(11)

EP 1 124 957 A1

(12)

(43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99971851.3 (22) Date of filing: 05.11.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C07K 14/435, G01N 33/542, G01N 33/533, G01N 33/84 (86) International application number: PCT/GB9903/654 (87) International publication number: WO 0028/025 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.11.1998 GB 9824357 (71) Applicant: University of Wales College of Medicine Cardiff,South Glam CF4 4XN (GB)	(72) Inventor: CAMPBELL, Anthony, Keith PenarthVale of Glamorgan CF65 5RF (GB) (74) Representative: Newell, William Joseph et al Wynne-Jones, Lainé & JamesMorgan Arcade Chambers33 St. Mary Street Cardiff, CF10 1AF Cardiff, CF10 1AF (GB)