(19)
(11) EP 1 124 970 A1

(12)

(43) Date of publication:
22.08.2001 Bulletin 2001/34

(21) Application number: 99951003.5

(22) Date of filing: 27.10.1999
(51) International Patent Classification (IPC)7C12N 15/55, C12N 9/18, C12N 15/86, C12N 5/10
(86) International application number:
PCT/GB9903/551
(87) International publication number:
WO 0024/910 (04.05.2000 Gazette 2000/18)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 28.10.1998 GB 9823647
28.10.1998 GB 9823648

(71) Applicant: SMITHKLINE BEECHAM PLC
Brentford,Middlesex TW8 9EP (GB)

(72) Inventors:
  • Boyd, Helen,SmithKline Beecham Pharm.
    Harlow,Essex CM19 5AW (GB)
  • Tew, David Graham,SmithKline Beecham Pharm.
    King of Prussia, PA 19406 (US)

(74) Representative: Connell, Anthony Christopher 
GlaxoSmithKline,Two New Horizons Court
Brentford, Middlesex TW8 9EP
Brentford, Middlesex TW8 9EP (GB)

   


(54) PROCESS OF PURIFICATION OF LOW DENSITY LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2 USING IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY