(19)

(11)

EP 1 124 976 A1

(12)

(43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99971042.9 (22) Date of filing: 27.10.1999

(51) International Patent Classification (IPC)7: C12N 15/86, C12N 5/10 (86) International application number: PCT/NL9900/663 (87) International publication number: WO 0024/916 (04.05.2000 Gazette 2000/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.10.1998 EP 98203635 (71) Applicant: Crucell Holland B.V. 2333 CN Leiden (NL)	(72) Inventors: SCHOUTEN, Govert, Johan NL-2321 AR Leiden (NL) BOUT, Abraham NL-2751 AR Moerkapelle (NL) PAU, Maria, Grazia NL-2311 SK Leiden (NL) (74) Representative: Prins, Adrianus Willem et al Vereenigde,Nieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)