(19)

(11)

EP 1 124 985 A1

(12)

(43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99971864.6 (22) Date of filing: 05.11.1999

(51) International Patent Classification (IPC)7: C12Q 1/02, C12Q 1/26, C12Q 1/68, G01N 31/00, G01N 33/00, G01N 33/15, G01N 33/53, C07C 61/06, C12N 1/21, C12N 9/64, C12N 9/50, C12N 15/09, C07K 1/22, C07K 14/53, C07K 14/525, A61K 38/19, A61K 49/00 (86) International application number: PCT/US9926/133 (87) International publication number: WO 0028/072 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.11.1998 US 107404 P (71) Applicant: Emory University Atlanta, Georgia 30322 (US)	(72) Inventors: KINKADE, Joseph, M., Jr. Decatur, GA 30033 (US) SHAPIRA, Raymond Atlanta, GA 30329 (US) JENSEN, Peter, E. Snellville, GA 30078 (US) LE, Ngoc-Anh Decatur, GA 30033 (US) POHL, Jan Doraville, GA 30340 (US) BROWN, W., Virgil Atlanta, GA 30305 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)