(19)

(11)

EP 1 124 991 A1

(12)

(43) Date of publication: 22.08.2001 Bulletin 2001/34 (21) Application number: 99971046.0 (22) Date of filing: 22.10.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, G06F 19/00 (86) International application number: PCT/US9924/851 (87) International publication number: WO 0024/934 (04.05.2000 Gazette 2000/18)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.10.1998 US 105435 P (71) Applicant: YALE UNIVERSITY New Haven, CT 06510 (US)	(72) Inventors: KUNG, Patrick, C. Cambridge, MA 02138 (US) CHENG, Yung-Chi Woodbridge, CT 06525 (US) (74) Representative: Goulard, Sophie et al Cabinet Ores,6, Avenue de Messine 75008 Paris Cedex 75008 Paris Cedex (FR)