(19)

(11)

EP 1 126 834 A1

(12)

(43) Date of publication: 29.08.2001 Bulletin 2001/35 (21) Application number: 99951876.4 (22) Date of filing: 12.10.1999

(51) International Patent Classification (IPC)7: A61K 31/135, A61P 25/04, A61P 19/02 // A61K31:137 (86) International application number: PCT/US9923/513 (87) International publication number: WO 0025/769 (11.05.2000 Gazette 2000/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.11.1998 US 106567 P (71) Applicant: Ortho-McNeil Pharmaceutical, Inc. Raritan, NJ 08869-0602 (US)	(72) Inventors: KAMIN, Marc West Windsor, NJ 08550 (US) OLSON, William Princeton, NJ 08540 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)