(19)

(11)

EP 1 127 055 A2

(12)

(88) Date of publication A3: 27.07.2000 (43) Date of publication: 29.08.2001 Bulletin 2001/35 (21) Application number: 99955034.6 (22) Date of filing: 15.10.1999

(51) International Patent Classification (IPC)7: C07D 273/00 (86) International application number: PCT/US9924/410 (87) International publication number: WO 0023/429 (27.04.2000 Gazette 2000/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.10.1998 US 104664 P (71) Applicants: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US) WAYNE STATE UNIVERSITY Detroit, MI 48202 (US) UNIVERSITY OF HAWAII Honolulu, HI 96822 (US)	(72) Inventors: AIKINS, James, Abraham Pendleton, IN 46064 (US) BRIGGS, Barbara, Shreve Indianapolis, IN 46236 (US) ZHANG, Tony, Yantao Indianapolis, IN 46236 (US) ZMIJEWSKI, Milton, Joseph, Junior Carmel, IN 46033 (US) (74) Representative: Burnside, Ivan John et al Eli Lilly and Company LimitedLilly Research CentreErl Wood Manor Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)