(19)

(11)

EP 1 127 144 A2

(12)

(88) Date of publication A3: 17.08.2000 (43) Date of publication: 29.08.2001 Bulletin 2001/35 (21) Application number: 99956903.1 (22) Date of filing: 04.11.1999

(51) International Patent Classification (IPC)7: C12N 15/82, C12N 15/52, C12N 9/00, C12N 5/10, G01N 33/50, C12Q 1/68 (86) International application number: PCT/US9925/950 (87) International publication number: WO 0028/053 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.11.1998 US 107275 P (71) Applicant: E.I. DU PONT DE NEMOURS AND COMPANY WilmingtonDelaware 19898 (US)	(72) Inventors: ALLEN, Stephen, M. Wilmington, DE 19810 (US) HUANG, Lisa, L. Hockessin, DE 19707 (US) FALCO, Saverio, Carl Arden, DE 19810 (US) RAFALSKI, Antoni, J. Wilmington, DE 19810 (US) (74) Representative: Webber, Philip Michael  Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)