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(11)

EP 1 129 076 A1

(12)

(43) Date of publication: 05.09.2001 Bulletin 2001/36 (21) Application number: 99961631.1 (22) Date of filing: 09.11.1999

(51) International Patent Classification (IPC)7: C07D 217/04, C07D 217/14, C07D 217/16, A61K 31/472, A61P 5/00, C07D 217/20, C07D 217/26, C07D 223/16, C07D 401/06, C07D 401/12, C07D 401/10, C07D 491/04, C07D 401/08 // (C07D491/04, 317:00), C07D221:00,(C07D491/04, 319:00), C07D221:00 (86) International application number: PCT/US9926/584 (87) International publication number: WO 0029/380 (25.05.2000 Gazette 2000/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.11.1998 US 151511 (71) Applicant: ABBOTT LABORATORIES Abbott Park,IL 60064-6050 (US)

(72) Inventors: HAVIV, Fortuna Deerfield, IL 60015 (US) DWIGHT, Wesley, J. Evanston, IL 60202 (US) CRAWFORD, Bradley, W. Gurnee, IL 60031 (US) SWENSON, Rolf, E. Grayslake, IL 60030 (US) BRUNCKO, Milan Lake Bluff, IL 60044 (US) KAMINSKI, Michele, A. Beach Park, IL 60087 (US) FREY, Lisa, M. Mundelein, IL 60060 (US) DEMATTEI, John Gurnee, IL 60031 (US) GREER, Jonathan Chicago, IL 60045 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)