(19)

(11)

EP 1 129 104 A1

(12)

(43) Date of publication: 05.09.2001 Bulletin 2001/36 (21) Application number: 99971812.5 (22) Date of filing: 05.11.1999

(51) International Patent Classification (IPC)7: C07H 21/04, C12N 1/20, C12N 15/00, C12P 21/06 (86) International application number: PCT/US9925/747 (87) International publication number: WO 0027/862 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.11.1998 US 107725 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventors: FONG, Tung, M. Rahway, NJ 07065-0907 (US) VAN DER PLOEG, Leonardus, H., T. Rahway, NJ 07065-0907 (US) HUANG, Ruey-Ruey, C. Rahway, NJ 07065-0907 (US) (74) Representative: Hiscock, Ian James et al European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)