(19)

(11)

EP 1 129 350 A1

(12)

(43) Date of publication: 05.09.2001 Bulletin 2001/36 (21) Application number: 99952701.3 (22) Date of filing: 04.11.1999

(51) International Patent Classification (IPC)7: G01N 33/50, C12N 5/10, C12Q 1/68 (86) International application number: PCT/GB9903/648 (87) International publication number: WO 0028/323 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 10.11.1998 GB 9824501 (71) Applicant: AstraZeneca AB 151 85 Södertälje (SE)	(72) Inventors: GREEN, Isabelle Cheshire SK10 4TG (GB) CHARLES, Andrew, David Cheshire SK10 4TG (GB) (74) Representative: Bill, Kevin et al AstraZeneca UK Limited,Global Intellectual Property, IP Services,P.O. Box 272,Mereside,Alderley Park Macclesfield, Cheshire SK10 4GR Macclesfield, Cheshire SK10 4GR (GB)