(19)
(11) EP 1 131 102 A2

(12)

(88) Date of publication A3:
31.08.2000

(43) Date of publication:
12.09.2001 Bulletin 2001/37

(21) Application number: 99960268.3

(22) Date of filing: 10.11.1999
(51) International Patent Classification (IPC)7A61K 45/06
(86) International application number:
PCT/US9926/623
(87) International publication number:
WO 0027/382 (18.05.2000 Gazette 2000/20)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 12.11.1998 US 108105 P
21.01.1999 GB 9901338

(71) Applicant: Merck & Co., Inc.
Rahway,New Jersey 07065-0907 (US)

(72) Inventors:
  • BLOCK, Gilbert, A.
    Rahway, NJ 07065-0907 (US)
  • LINES, Christopher, R.
    Rahway, NJ 07065-0907 (US)

(74) Representative: Horgan, James Michael Frederic 
Merck & Co., Inc.,Terlings Park,Eastwick Road
Harlow,Essex CM20 2QR
Harlow,Essex CM20 2QR (GB)

   


(54) COMBINATION OF A GABA-A ALPHA 5 INVERSE AGONIST AND COX-2 INHIBITOR, NSAID, ESTROGEN OR VITAMIN E