COMBINATION OF A GABA-A ALPHA 5 INVERSE AGONIST AND COX-2 INHIBITOR, NSAID, ESTROGEN OR VITAMIN E - Patent 1131102

(19)

(11)

EP 1 131 102 A2

(12)

(88)	Date of publication A3:
	31.08.2000

(43)	Date of publication:
	12.09.2001 Bulletin 2001/37

(21)	Application number: 99960268.3

(22)	Date of filing: 10.11.1999

(51)	International Patent Classification (IPC)⁷: A61K 45/06

(86)	International application number:
	PCT/US9926/623

(87)	International publication number:
	WO 0027/382 (18.05.2000 Gazette 2000/20)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	AL LT LV MK RO SI

(30)

Priority:

12.11.1998 US 108105 P
21.01.1999 GB 9901338

(71)	Applicant: Merck & Co., Inc.
	Rahway,New Jersey 07065-0907 (US)

(72)	Inventors:
	BLOCK, Gilbert, A. Rahway, NJ 07065-0907 (US) LINES, Christopher, R. Rahway, NJ 07065-0907 (US)

(74)	Representative: Horgan, James Michael Frederic
	Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)

(54)	COMBINATION OF A GABA-A ALPHA 5 INVERSE AGONIST AND COX-2 INHIBITOR, NSAID, ESTROGEN OR VITAMIN E