(19)

(11)

EP 1 131 295 A1

(12)

(43) Date of publication: 12.09.2001 Bulletin 2001/37 (21) Application number: 99961001.7 (22) Date of filing: 19.11.1999

(51) International Patent Classification (IPC)7: C07D 215/52, A61K 31/47, C07D 401/06, C07D 471/10, C07D 401/12, C07D 401/14, C07D 487/04, C07D 491/10, C07D 487/10, C07D 413/10, C07D 417/12 // (C07D471/10, 235:00), C07D221:00,(C07D487/04, 241:00), C07D209:00,(C07D491/10, 317:00), C07D221:00,(C07D471/10, 221:00), C07D209:00, C07D487:10, C07D209:00 (86) International application number: PCT/EP9909/115 (87) International publication number: WO 0031/037 (02.06.2000 Gazette 2000/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.11.1998 GB 9825552 20.11.1998 GB 9825553 (71) Applicants: Smithkline Beecham S.p.A. 20021 Baranzate di Bollate (MI) (IT) SMITHKLINE BEECHAMLABORATOIRES PHARMACEUTIQUES 92731 Nanterre Cédex (FR)

(72) Inventors: FARINA, C.,SmithKline Beecham S.p.A. I-20021 Baranzate di Bollate (IT) GIARDINA, G.,SmithKline Beecham S.p.A. I-20021 Baranzate di Bollate (IT) GRUGNI, M,SmithKline Beecham S.p.A. I-20021 Baranzate di Bollate (IT) MORVAN, M.,SmithKline Beecham Lab. Pharm. B.P.58 35762 St-G (FR) NADLER, G M.M.G.,SmithKlineBeecham Lab.Pharm. 4, rue du Chesnay-Beauregard (FR) RAVEGLIA, Luca, Francesco I-20021 Baranzate di Bollate (IT) (74) Representative: Rutter, Keith et al GlaxoSmithKline,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)