(19)

(11)

EP 1 131 296 A2

(12)

(88) Date of publication A3: 04.01.2001 (43) Date of publication: 12.09.2001 Bulletin 2001/37 (21) Application number: 99972525.2 (22) Date of filing: 18.11.1999

(51) International Patent Classification (IPC)7: C07D 221/16, C07D 213/81 (86) International application number: PCT/US9926/010 (87) International publication number: WO 0030/589 (02.06.2000 Gazette 2000/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.11.1998 US 197003 (71) Applicant: SCHERING CORPORATION Kenilworth,New Jersey 07033-0530 (US)

(72) Inventors: BERNARD, Charles, F. Agoura Hills, CA 91301 (US) CASEY, Michael Dublin 16,County Dublin (IE) CHEN, Frank, Xing Plainsboro, NJ 08536 (US) GROGAN, Denise, C. Frankfield,Cork,County Cork (IE) POIRIER, Marc Edison, NJ 08817 (US) WILLIAMS, Robert, P. Enniskerry,County Wicklow (IE) WONG, Yee-Shing Florham Park, NJ 07932 (US) WU, George, G. Basking Ridge, NJ 07920 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)