(19)

(11)

EP 1 131 349 A2

(12)

(88) Date of publication A3: 05.10.2000 (43) Date of publication: 12.09.2001 Bulletin 2001/37 (21) Application number: 99972644.1 (22) Date of filing: 19.11.1999

(51) International Patent Classification (IPC)7: C07K 14/47, C12N 15/11 (86) International application number: PCT/US9927/428 (87) International publication number: WO 0031/133 (02.06.2000 Gazette 2000/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.11.1998 US 109333 P 25.11.1998 US 110033 P 30.11.1998 US 110277 P 23.04.1999 US 298731 09.07.1999 US 350614 09.07.1999 US 350874 21.09.1999 US 399913 21.09.1999 US 400492 (71) Applicants: Millennium Pharmaceuticals, Inc. Cambridge,Massachusetts 02139 (US) AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: RHODES, Kenneth Neshanic Station, NJ 08853 (US) BETTY, Maria Mt. Laurel, NJ 08853 (US) LING, Huai-Ping Princeton, NJ 08550 (US) AN, Wenqian Framingham, MA 01702 (US) (74) Representative: Lock, Graham James et al Fry Heath & Spence,The Old College,53 High Street Horley,Surrey RH6 7BN Horley,Surrey RH6 7BN (GB)