(19)

(11)

EP 1 131 431 A2

(12)

(88) Date of publication A3: 09.11.2000 (43) Date of publication: 12.09.2001 Bulletin 2001/37 (21) Application number: 99963894.3 (22) Date of filing: 10.11.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12Q 1/68, A61K 38/17, C07K 14/47, G01N 33/68, C07K 16/18, A61P 1/00 (86) International application number: PCT/US9926/788 (87) International publication number: WO 0028/033 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.1998 US 107821 P (71) Applicant: Digital Gene Technologies Inc. La Jolla, CA 92037 (US)

(72) Inventors: BAUM, Peter, Robert Seattle, WA 98115 (US) DUBOSE, Robert, Finley Bellevue, WA 98006 (US) SIMS, John, E. Seattle, WA 98105 (US) YOUAKIM, Adel Seatle, WA 98116 (US) HASEL, Karl, W. Solana Beach, CA 92075 (US) HILBUSH, Brian, S. San Diego, CA 92130 (US) (74) Representative: Grund, Martin, Dr. et al Dr. Volker Vossius,Patentanwaltskanzlei,Holbeinstrasse 5 81679 München 81679 München (DE)