(19)

(11)

EP 1 133 282 A1

(12)

(43) Date of publication: 19.09.2001 Bulletin 2001/38 (21) Application number: 99962868.8 (22) Date of filing: 24.11.1999

(51) International Patent Classification (IPC)7: A61K 9/14 (86) International application number: PCT/US9927/981 (87) International publication number: WO 0030/617 (02.06.2000 Gazette 2000/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.11.1998 US 110032 P (71) Applicant: CIMA LABS INC. Eden Prairie, MN 55344-9361 (US)	(72) Inventors: HOLT, Kris, E. Maple Grove, MN 55369 (US) KHANKARI, Rajendra, K. Maple Grove, MN 55311 (US) HONTZ, John Plymouth, MN 55442 (US) (74) Representative: Harrison, Michael Charles et al Albihns GmbH,Grasserstrasse 10 80339 München 80339 München (DE)