(19)

(11)

EP 1 133 493 A1

(12)

(43) Date of publication: 19.09.2001 Bulletin 2001/38 (21) Application number: 98961822.8 (22) Date of filing: 27.11.1998

(51) International Patent Classification (IPC)7: C07D 417/10, A61K 31/42, C07D 263/20, C07D 413/10 (86) International application number: PCT/US9825/308 (87) International publication number: WO 0032/599 (08.06.2000 Gazette 2000/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventors: HESTER, Jackson, B., Jr. Galesburg, MI 49053 (US) NIDY, Eldon, George Kalamazoo, MI 49001 (US) PERRICONE, Salvatore, Charles Delton, MI 49046 (US) POEL, Toni-Jo Wayland, MI 49348 (US) (74) Representative: Perry, Robert Edward et al GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)