(19)

(11)

EP 1 133 513 A1

(12)

(43) Date of publication: 19.09.2001 Bulletin 2001/38 (21) Application number: 99958709.0 (22) Date of filing: 29.10.1999

(51) International Patent Classification (IPC)7: C07H 21/00, C07H 21/02, C07H 21/04, C12Q 1/68 (86) International application number: PCT/US9925/497 (87) International publication number: WO 0026/226 (11.05.2000 Gazette 2000/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.11.1998 US 106829 P 29.03.1999 US 126683 P (71) Applicant: Yale University New Haven, CT 06520-8336 (US)	(72) Inventors: BREAKER, Ronald, R. Guilford, CT 06437 (US) SOUKUP, Garrett A. North Branford, CT 06471 (US) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)