(19)

(11)

EP 1 133 692 A1

(12)

(43) Date of publication: 19.09.2001 Bulletin 2001/38 (21) Application number: 99956197.0 (22) Date of filing: 23.11.1999

(51) International Patent Classification (IPC)7: G01N 33/50, G01N 33/92, G01N 33/576, G01N 33/68, C07K 14/18, A61K 39/29, A61K 38/16 (86) International application number: PCT/GB9903/906 (87) International publication number: WO 0031/532 (02.06.2000 Gazette 2000/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.11.1998 GB 9825951 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: HOPE, Graham Jordanhill,Glasgow G13 1QJ (GB) MCLAUCHLAN, John Bishopbriggs,Glasgow G64 1HA (GB) (74) Representative: Holliday, Louise Caroline  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)