(19)

(11)

EP 1 135 126 A2

(12)

(88) Date of publication A3: 17.08.2000 (43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99968070.5 (22) Date of filing: 07.12.1999

(51) International Patent Classification (IPC)7: A61K 31/425 (86) International application number: PCT/US9928/700 (87) International publication number: WO 0033/837 (15.06.2000 Gazette 2000/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.12.1998 US 111183 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventor: LAGO, Maria, A. Audubon, PA 19403 (US) (74) Representative: Waters, David Martin  GlaxoSmithKline,Corporate Intellectual Property,Two New Horizons,Court Brentford,Middlesex TW8 9EP Brentford,Middlesex TW8 9EP (GB)