(19)

(11)

EP 1 135 144 A1

(12)

(43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99963011.4 (22) Date of filing: 02.12.1999

(51) International Patent Classification (IPC)7: A61K 35/00 (86) International application number: PCT/US9928/751 (87) International publication number: WO 0032/152 (08.06.2000 Gazette 2000/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.12.1998 US 110570 P (71) Applicant: Princeton University Princeton, NJ 08544-0036 (US)	(72) Inventors: BASSLER, Bonnie,Princeton University Princeton, NJ 08544-0036 (US) Surette, Michael G. Alberta (CA) (74) Representative: Van Malderen, Joelle et al Office Van Malderen,Place Reine Fabiola 6/1 1083 Bruxelles 1083 Bruxelles (BE)