(19)

(11)

EP 1 135 167 A2

(12)

(88) Date of publication A3: 17.08.2000 (43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99966115.0 (22) Date of filing: 09.12.1999

(51) International Patent Classification (IPC)7: A61K 47/48, A61K 39/385, C07H 15/08, C07H 15/18, C07H 15/26 (86) International application number: PCT/US9929/336 (87) International publication number: WO 0033/887 (15.06.2000 Gazette 2000/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.12.1998 US 111639 P 08.12.1999 US 457875 (71) Applicant: LA JOLLA PHARMACEUTICAL San Diego, California 92121 (US)	(72) Inventors: JACK, Richard, M. Del Mar, CA 92014 (US) JONES, David, S. San Diego, CA 92121 (US) YU, Lin San Diego, CA 92128 (US) ENGLE, Steven, B. Del Mar, CA 92014 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)