(19)

(11)

EP 1 135 407 A1

(12)

(43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99958786.8 (22) Date of filing: 04.11.1999

(51) International Patent Classification (IPC)7: C07K 14/00, C07K 14/435, C12P 21/00, C12N 15/12, C12N 15/63, C07K 16/18, A61K 39/00, C12N 1/13, C12N 1/19, C12N 1/21, C12N 5/10 (86) International application number: PCT/US9926/104 (87) International publication number: WO 0029/430 (25.05.2000 Gazette 2000/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.11.1998 US 191500 (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventors: VENEZIA, Domenick Seattle, WA 98117 (US) GROSSMANN, Angelika Seattle, WA 98115 (US) (74) Representative: MacLean, Martin Robert et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)