(19)

(11)

EP 1 135 464 A2

(12)

(88) Date of publication A3: 10.08.2000 (43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99949225.9 (22) Date of filing: 14.10.1999

(51) International Patent Classification (IPC)7: C12N 5/08, A61K 35/12, A61K 48/00 (86) International application number: PCT/GB9903/402 (87) International publication number: WO 0022/097 (20.04.2000 Gazette 2000/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.10.1998 GB 9822434 (71) Applicant: THE MATHILDA AND TERENCE KENNEDY INSTITUTE OF RHEUMATOLOGY London W6 8LH (GB)	(72) Inventors: ZVAIFLER, Nathan, Joseph La Jolla, CA 92093-0664 (US) MARINOVA-MUTAFCHIEVA, Lilia London W6 8LH (GB) MAINI, Ravinder, Nath London W6 8LH (GB) (74) Representative: Elsy, David et al Withers & Rogers,Goldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)