(19)

(11)

EP 1 135 475 A1

(12)

(43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99921757.3 (22) Date of filing: 06.05.1999

(51) International Patent Classification (IPC)7: C12N 9/72, C12N 9/68, C07K 7/06, A61K 38/08, A61K 38/48 (86) International application number: PCT/US9909/991 (87) International publication number: WO 0032/759 (08.06.2000 Gazette 2000/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.12.1998 US 110588 P (71) Applicant: Oklahoma Medical Research Foundation Oklahoma CityOklahoma 73104 (US)	(72) Inventors: LIN, Xinli Edmond, OK 73003 (US) ZHANG, Xuejun, C. Edmond, OK 73003 (US) TANG, Jordan, J., N. Edmond, OK 73034 (US) (74) Representative: Miles, John Stephen  Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)