(19)

(11)

EP 1 135 491 A2

(12)

(88) Date of publication A3: 19.10.2000 (43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99965077.3 (22) Date of filing: 30.11.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C07K 16/18, C12N 15/62, A61K 38/17 (86) International application number: PCT/US9928/409 (87) International publication number: WO 0032/778 (08.06.2000 Gazette 2000/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.12.1998 WO PCT/US98/25108 16.12.1998 US 112850 P 22.12.1998 US 113296 P 20.07.1999 US 144758 P 26.07.1999 US 145698 P (71) Applicant: Genentech, Inc. South San Francisco, CA 94080-4990 (US)

(72) Inventors: CHEN, Jian Princeton, NJ 08540 (US) GODDARD, Audrey San Francisco, CA 94131 (US) GURNEY, Austin, L. Belmont, CA 94002 (US) HILLAN, Kenneth San Francisco, CA 94114 (US) NAPIER, Mary Hillsborough, CA 94010 (US) WOOD, William, I. Hillsborough, CA 94010 (US) (74) Representative: Denison, Christopher Marcus et al Mewburn EllisYork House23 Kingsway GB-London WC2B 6HP GB-London WC2B 6HP (GB)