(19)

(11)

EP 1 135 525 A2

(12)

(88) Date of publication A3: 05.10.2000 (43) Date of publication: 26.09.2001 Bulletin 2001/39 (21) Application number: 99961726.9 (22) Date of filing: 19.11.1999

(51) International Patent Classification (IPC)7: C12Q 1/68, G01N 33/53 (86) International application number: PCT/US9927/525 (87) International publication number: WO 0029/624 (25.05.2000 Gazette 2000/21)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.11.1998 US 109082 P 27.01.1999 US 117389 P 07.05.1999 US 132976 P (71) Applicant: Cygene Inc. Sunrise, FL 33351 (US)	(72) Inventor: RAMBERG, Elliot, R. Delray Beach, FL 33446 (US) (74) Representative: Thomas, Philip John Duval  Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)