(19)

(11)

EP 1 137 460 A2

(12)

(88) Date of publication A3: 09.11.2000 (43) Date of publication: 04.10.2001 Bulletin 2001/40 (21) Application number: 99959520.0 (22) Date of filing: 06.12.1999

(51) International Patent Classification (IPC)7: A61P 15/10, A61P 3/10, A61K 31/17, A61K 31/155, A61K 31/195, A61K 31/416, A61K 31/426 (86) International application number: PCT/GB9904/095 (87) International publication number: WO 0035/431 (22.06.2000 Gazette 2000/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 11.12.1998 GB 9827393 (71) Applicant: UNIVERSITY COLLEGE LONDON London WC1E 6BT (GB)	(72) Inventors: CELLEK, Selim,The Wolfson Inst. for Bio. Res. London W1P 9LN (GB) MONCADA, Salvador,The Wolfson Inst. for Bio. Res. London W1P 9LN (GB) (74) Representative: Woods, Geoffrey Corlett et al J.A. KEMP & CO.Gray's Inn14 South Square London WC1R 5JJ London WC1R 5JJ (GB)