(19)

(11)

EP 1 137 633 A2

(12)

(88) Date of publication A3: 23.11.2000 (43) Date of publication: 04.10.2001 Bulletin 2001/40 (21) Application number: 99965132.6 (22) Date of filing: 06.12.1999

(51) International Patent Classification (IPC)7: C07C 335/20, C07D 207/14, C07D 207/09, C07D 211/58, C07D 261/08, A61K 31/17, A61K 31/40, A61K 31/445, A61K 31/42 (86) International application number: PCT/US9928/844 (87) International publication number: WO 0034/237 (15.06.2000 Gazette 2000/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 09.12.1998 US 208316 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: BLOOM, Jonathan, David Nyack, NY 10960 (US) DIGRANDI, Martin, Joseph Piermont, New York 10968 (US) DUSHIN, Russell, George Garrison, NY 10524 (US) LANG, Stanley, Albert La Costa, California 92009 (US) O'HARA, Bryan, Mark Norwood, New Jersey 07648 (US) (74) Representative: Walters, Philip Bernard William  Wyeth Laboratories,Patents & Trade Marks Department,Huntercombe Lane South,Taplow Maidenhead,Berkshire SL6 0PH Maidenhead,Berkshire SL6 0PH (GB)