(19)

(11)

EP 1 137 774 A2

(12)

(88) Date of publication A3: 09.11.2000 (43) Date of publication: 04.10.2001 Bulletin 2001/40 (21) Application number: 99967225.6 (22) Date of filing: 08.12.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/475, C07K 16/22, C12N 5/10, C12N 5/12, A61K 38/18, A61K 35/12 (86) International application number: PCT/US9928/975 (87) International publication number: WO 0034/475 (15.06.2000 Gazette 2000/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.12.1998 US 111626 P (71) Applicant: Amgen Inc. Thousand Oaks, CA 91320-1799 (US)	(72) Inventors: SIMONET, William, Scott Thousand Oaks, CA 91360 (US) ASUNCION, Franklin, J. Simi Valley, CA 93065 (US) MIN, Hosung Sherman Oaks, CA 91401 (US) JING, Shuqian Thousand Oaks, CA 91362 (US) (74) Representative: Richardson, Kate et al Forrester & Boehmert,Pettenkoferstrasse 20-22 80336 München 80336 München (DE)