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(11)

EP 1 137 779 A2

(12)

(88) Date of publication A3: 05.10.2000 (43) Date of publication: 04.10.2001 Bulletin 2001/40 (21) Application number: 99971855.4 (22) Date of filing: 09.11.1999

(51) International Patent Classification (IPC)7: C12N 15/34, C07K 14/01, C12P 21/00, C12N 7/00, C12N 7/02, C07K 16/08, A61K 39/12, A61K 39/42, C07K 19/00, G01N 33/569, C12Q 1/68, C12Q 1/70, A61P 1/00, A61P 35/00 (86) International application number: PCT/EP9908/566 (87) International publication number: WO 0028/039 (18.05.2000 Gazette 2000/20)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.1998 IT MI982437 30.04.1999 IT MI990923 14.05.1999 EP 99830298 16.07.1999 EP 99113932 (71) Applicant: DiaSorin International Inc. New York, NY 10019 (US)

(72) Inventors: PRIMI, Daniele I-25128 Brescia (IT) FIORDALISI, Gianfranco I-25043 Breno (IT) MANTERO, Giovanni, Lorenzo I-25020 Milzano (IT) MATTIOLI, Sonia I-25126 Brescia (IT) SOTTINI, Alessandra I-25121 Brescia (IT) BONELLI, Fabrizio I-15033 Casale Monferrato (IT) VAGLINI, Laura I-10023 Chieri (IT) OLIVERO, Paolo I-10126 Torino (IT) DAL CORSO, Andrea I-10064 Pinerolo (IT) BONELLI, Marco I-10141 Torino (IT) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)