(19)

(11)

EP 1 137 949 A1

(12)

(43) Date of publication: 04.10.2001 Bulletin 2001/40 (21) Application number: 99963400.9 (22) Date of filing: 07.12.1999

(51) International Patent Classification (IPC)7: G01N 33/92, G01N 33/68, G01N 33/74, G01N 33/573, C12Q 1/44, A61K 31/20, C07F 9/10 (86) International application number: PCT/EP9909/546 (87) International publication number: WO 0034/791 (15.06.2000 Gazette 2000/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.12.1998 GB 9826899 (71) Applicant: KNOLL AKTIENGESELLSCHAFT 67061 Ludwigshafen (DE)	(72) Inventors: HEAL, David, John Nottingham NG1 1GF (GB) MARTIN, Keith, Frank Nottingham NG1 1GF (GB) THOMPSON, Kevin, Stuart, John Nottingham NG1 1GF (GB) (74) Representative: Nash, David Allan  Haseltine Lake & Co.,Imperial House, 15-19 Kingsway London WC2B 6UD London WC2B 6UD (GB)