(19)

(11)

EP 1 140 120 A2

(12)

(88) Date of publication A3: 02.11.2000 (43) Date of publication: 10.10.2001 Bulletin 2001/41 (21) Application number: 99966502.9 (22) Date of filing: 20.12.1999

(51) International Patent Classification (IPC)7: A61K 35/00, C07H 21/02, C07H 21/04, C12N 1/21, C12N 1/15, C12N 1/19, C12N 5/14, C12N 15/11, C12N 15/63, C12N 15/85, C12N 15/86 (86) International application number: PCT/US9930/452 (87) International publication number: WO 0039/136 (06.07.2000 Gazette 2000/27)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.12.1998 US 113804 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: YOUNG, Paul, E. Gaithersburg, MD 20878 (US) RUBEN, Steven, M. Laytonsville, MD 20882 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)